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Reversible Parkinsonism and Cognitive Impairment with Chronic Valproate Use Neurol 47:626-635, Armon,C.,et al, 1996 See this aricle in Pubmed Article Abstract Following our initial report of the insidious development of reversible, valproate-induced hearing,motor,and cognitive dysfunction in two patients, we evaluated 36 patients in an epilepsy clinic who had been taking therapeutic levels of valproate for at least 12 months;29 of these patients were examined according to a prospective protocol.We observed varying degrees of parkinsonism and cognitive impairment,from none to severe.Discontinuation of valproate in 32 affected patients led to subjective and objective improvement on follow-up testing at least 3 months later.Improvement was greatest in patients who were affected most. We conclude that a syndrome of reversible parkinsonism and cognitive impairment may develop insidiously in patients who have been treated with valproate for more than 12 months.The association with valproate maybe overlooked due to the insidious onset.

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(click to filter results - removes previous filter) adverse drug reaction anticonvulsants anticonvulsants,cognitive function with anticonvulsants,untoward effects of cognition drug induced neurologic disorders intellectual deficit Parkinson disease Parkinson disease,drug induced sodium valproate sodium valproate,toxicity

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